Macau's medical facilities are modern and well advanced and there is no problem to receive any kind of treatment. The standards are as high as in most western countries.
It is very recommended to obtain a comprehensive health-insurance before arrival as medical costs can be quite expensive.
For 24 hour emergency, the following hospitals have good reputation:
Hospital Conde S. Januário (Government), Estrada do Visconde de S. Januário, Phone: 2831 3731
Kiang Wu Hospital (Private), Estrada Coelho do Amaral, Phone: 2837 1333
For other cases, that are not as urgent, you may contact one of the following medical centers:
Macau Oriental Health Centre (Tap Seac), Avenida conselheiro Ferreira de Almeida, Phone: 2852 2232
Centro Medico Diagnostico Popular, 181-187 Alameda Dr. Carlos d'Assumpção, Phone: 2852 4468 / 2857 7790
Southside Medical Centre, 18/F China law building, 405-409 Avenida Praia Grande, Phone: 2832 2283
Taipa Health Centre, Lardo de Ponte, Taipa, Phone: 2882 7096
For more details, you may also contact the Macau Health Department, phone: 2856 2404
Generally speaking, Macau is a clean city that maintains high standards of hygiene. That normally includes food centers and markets, where authentic food is prepared in cheap eateries. Most of these eateries and stalls are visited frequently by health-inspectors. However, it is always good to take precautions, especially if you want to eat seafood... just make sure that the place is reasonably clean before you order food.
Tap water in Macau should be safe to drink but the taste is not something to write home about... The pipeline is old in some parts of the city and the rust affects the water. Bottled water is not expensive and can be bought everywhere.
Vaccination certificates are not required usually. You might need to have a Yellow Fever vaccine if coming from a contaminated area (mostly Africa and Latin America). Check with your carriers before departure.
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You may also want to read about...
When to come? What to wear? What to bring?
Customs and Immigration
Visiting China and Hong Kong
Money, Communications, Time and other small daily stuff
Emergency - what to do in case of a problem